Leveraging historical data to optimize the number of covariates and their explained variance in the analysis of randomized clinical trials
January 11, 2022The amount of data collected from patients involved in clinical trials is continuously growing. All baseline patient characteristics are potential covariates that could be used to improve clinical trial analysis and power. However, the limited number of patients in phases I and II studies restricts the possible number of covariates included in the analyses. In
Type: Scientific Publication
Date: December 13, 2021
Conference: Statistical Methods in Medical Research Journal