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Insights

The placebo problem in pain: does baseline pain variability predict placebo response?

Recent reports have demonstrated a positive correlation between baseline pain variability and improvement in clinical trial patients receiving placebo, suggesting that patients with more highly variable reporting…

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Insights

Patients are people: a new take on patient-centricity

If you ask a dozen people in the pharmaceutical / biotech industry what the term “patient-centricity” means, you’re likely to get a dozen different answers. These may include…

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Insights

Predicting the placebo response in quality of life, sleep and fatigue

While significant placebo responses rates are often noted in clinical trials for indications like pain and depression, this issue can plague drug development in any therapeutic area…

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Insights

Should strong placebo responders be excluded from clinical trials?

Using Predictive Modeling to understand the impact on assay sensitivity The placebo response is a heavily studied and historically challenging phenomenon for drug developers. Strong placebo effect…

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Insights

How much of the measured treatment response in clinical trials is due to the placebo response?

Clinical trials measure efficacy of experimental therapies by comparing outcomes in patients receiving therapeutic interventions (treatment response) with patients receiving placebo (placebo response).

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Insights

The Importance of Patient Psychology in Health and Clinical Research

When we think about patient characteristics that influence health, disease, and clinical research, we tend to think about things like vital statistics, medical history and genetic makeup…

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