Leverage the power of Placebell

The only placebo effect quantification tool to optimize clinical trial success.

Not managing the placebo response puts your clinical trials at risk -
a risk you can now avoid. Take action today.

Quantify the power of the mind.

To de-risk your phase ll and lll clinical trials starting today.

Every clinical trial patient is unique - and so is their placebo response. That's why high failure rates in Phases II and III are still too common. How are you accounting for the placebo response in your clinical trials?

Placebell offers a sophisticated, yet simple, AI-based method to predict and account for individual patients' placebo responsiveness in clinical trials. Deployed with only minimal changes to protocols and with no risk to your data analysis, Placebell helps sponsors bring life-saving therapies to market safely and efficiently.


Increase in study power


Decrease in variability


Reduction of type ll error


Placebell has been deployed in more than a dozen studies across multiple indications.


low risk

Placebell poses no mathematical or operational negative impact on the trial or data.



Placebell uses advanced AI and machine learning to reduce variability in efficacy evaluation.

Step 1 Assess patient psychological profile

Patients are administered a validated questionnaire only once in a trial. This measures personality traits, expectations and other factors.

Step 2 Calculate placebo response through our AI-powered platform

The Placebell Covariate - defining each patient's relative placebo responsiveness - is calculated using a machine learning-based model.

Step 3 Define and use covariates to de-risk trials

The Placebell©TM Covariate can then be used in statistical analysis to decrease variance and increase study power.

Disease areas where Placebell can help you achieve better phase 2 and 3 results.

Women's health
Gastrointestinal disease
And many more

The next frontier in clinical research & patient management

We’re proud to be leading the charge into the next era of drug development.
Cognivia helps clinical trials reduce data variability, empower decision-making, and accelerate the launch of new therapies.
Tell us about your clinical trial below and we’ll be in touch.

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