Placebo-controlled, randomized clinical trials are the gold standard to evaluate drug safety and efficacy in drug development; yet, distinguishing true drug efficacy from the placebo response presents a significant challenge. This white paper examines the issue of the placebo response from multiple angles, and presents the background and scientific data resulting from the development of Placebell©™, our innovative approach to reduce the impact of the placebo response in clinical trials.

Topics include:

• The challenge of the placebo response in clinical trials
• Existing methods to manage the placebo response in drug development
• The development of the Placebell^©™ method
• Clinical data using Placebell^©™ in neuropathic pain
• Expansion of Placebell^©™ to indications outside of pain

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