Placebo Response

In analgesia randomized clinical trials (RCTs), the magnitude of the placebo response tends to increase with the year of trial completion, including in neuropathic pain trials.

This proof-of-concept study on peripheral neuropathic pain patients investigates the potential influence
of the investigator on the placebo response in RCTs while manipulating different variables, including
patient expectation, conditioning and prior experiences, observational and social learning.