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Embracing Human Complexity in Clinical Research
As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…
Leveraging Historical Data For High-dimensional Covariate-adaptive Randomization, A Machine Learning Approach.
There is a continuous growth in data collected in clinical trials. Many of those patient’s characteristics are potential…
Correcting For The Individual Patient Regression To The Mean Effect
Often, the primary endpoint of RCTs is defined as a change from baseline of a continuous outcome. In…
Interview on The Bio Report Podcast
Erica Smith, VP of Business Development, speaks with Daniel Levin of The Bio Report Podcast about the Placebell©™ method to reduce the impact of the placeb response in drug development”.
The Case Against Excluding High Placebo Responders from Clinical Trials
Drug developers have been struggling with the placebo response for decades, as a strong placebo effect diminishes the ability to distinguish pharmacologic treatment efficacy of an experimental…
Putting Patient Uniqueness at the heart of Innovation
Access to innovative therapies remains an issue. In certain diseases, the magnitude and variability of individuals’ placebo response…
Patient-Centric Approach To Characterizing Placebo response
Learn about how Tools4Patient considers the placebo response of each individual patient in clinical trials as a central part of the Placebell© methodology.
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