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Embracing Human Complexity in Clinical Research
As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…
Multifactorial Aspect Of The Placebo Analgesia Response In Peripheral Neuropathic Patients
The placebo response exerts a confusing influence when testing the statistically significant superiority of active compounds compared to…
Characterization And Prediction Of Placebo Responders In Peripheral Neuropathic Patients In A 4-week Analgesic Clinical Trial
In analgesia randomized clinical trials (RCTs), the magnitude of the placebo response tends to increase with the year…
Do Environmental Parameters Influence The Prediction Of The Placebo Response?
This proof-of-concept study on peripheral neuropathic pain patients investigates the potential influence of the investigator on the placebo…
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