Publications

Multifactorial Aspect Of The Placebo Analgesia Response In Peripheral Neuropathic Patients

August 7, 2016

The placebo response exerts a confusing influence when testing the statistically significant superiority of active compounds compared to placebo in analgesia randomized clinical trials (RCTs). Furthermore, the magnitude of this effect has tended to increase over time with the year of trial completion, including in neuropathic pain trials.

Type: Scientific Poster

Authors: Alvaro Pereira, PHD; Samuel Branders, PHD; Christian Dualé, MD PHD; Fréderic Clermont, PHD; Pierre Gramme, MS; Chantal Gossuin, PHARMD; Dominique Demolle, PHD.

Date: September 2, 2016

Conference: International Association for the Study of Pain Conference

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Characterization And Prediction Of Placebo Responders In Peripheral Neuropathic Patients In A 4-week Analgesic Clinical Trial

August 7, 2016

In analgesia randomized clinical trials (RCTs), the magnitude of the placebo response tends to increase with the year of trial completion, including in neuropathic pain trials.

Type: Scientific Poster

Authors: Alvaro Pereira, PHD; Christian Dualé, MD PHD; Frédéric Clermont, PHD, Pierre Gramme, MS; Samuel Branders, PHD; Chantal Gossuin, PHARMD; Dominique Demolle, PHD

Date: March 1, 2016

Conference: American Pain Society Conference

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Do Environmental Parameters Influence The Prediction Of The Placebo Response?

August 7, 2016

This proof-of-concept study on peripheral neuropathic pain patients investigates the potential influence
of the investigator on the placebo response in RCTs while manipulating different variables, including
patient expectation, conditioning and prior experiences, observational and social learning.

Type: Scientific Poster

Authors: Dominique Demolle, PHD; Samuel Branders, PHD; Chantal Gossuin, PHARMD; Fréderic Clermont, PHD; Christian Dualé, MD PHD; Alvaro Pereira, PHD

Conference: DIA Annual Conference

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