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Correcting For The Individual Patient Regression To The Mean Effect
Often, the primary endpoint of RCTs is defined as a change from baseline of a continuous outcome. In…
Putting Patient Uniqueness at the heart of Innovation
Access to innovative therapies remains an issue. In certain diseases, the magnitude and variability of individuals’ placebo response…
Leveraging historical data for high-dimensional regression adjustment, a machine learning approach.
The amount of data collected from patients involved in clinical trials is continuously growing. All those patient’s characteristics…
Baseline Pain Measurements As Predictors Of The Placebo Response In Neuropathic Patients
In analgesia randomized clinical trials (RCTs), the magnitude of the placebo response has a negative influence when testing…
Bayesian Modeling Of The Placebo Response In Neuropathic Pain
In analgesia randomized clinical trials (RCTs), the magnitude and the variability of the placebo response have a negative…
Multifactorial Aspect Of The Placebo Analgesia Response In Peripheral Neuropathic Patients
The placebo response exerts a confusing influence when testing the statistically significant superiority of active compounds compared to…
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