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Insights

Embracing Human Complexity in Clinical Research

As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…

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Publication

Predicting the Placebo response in OA to Improve the Precision of the Treatment Effect Estimation

Scientific Poster presented on April 2021 at the Osteoarthritis Research Society International Meeting. Purpose In osteoarthritis (OA) randomized…

Type: Scientific Poster
Authors: Samuel Branders1; Jamie Dananberg2; Frederic Clermont1; Ben Xie2; Benjamin Hsu2; J. Visich2; Akbar Khan2; Lauren Masaki2; Alvaro Pereira1 1-Tools4Patient, Mont-Saint-Guibert, Belgium 2-Unity Biotechnology, Inc., South San Francisco, CA
Conference: Osteoarthritis Research Society International (OARSI)
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Publication

Can Daily Self-Assessment Induce A Learning Effect Mitigating Pain Evaluation Error In Randomized Clinical Trials?

Scientific Poster presented on April 2021 at the Osteoarthritis Research Society International Meeting. Purpose Questionnaires assessing  patients’ pain level…

Type: Scientific Poster
Authors: Arthur Ooghe, M.E.; Samuel Branders, Ph.D.; Alvaro Pereira, Ph.D.
Conference: Osteoarthritis Research Society International (OARSI)
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Education

Patient Psychology: The Missing Link in Understanding Clinical Trial Data

Patients are central to clinical trials – but the impact of patient psychology on clinical trial results is still poorly understated. In this blog, we discuss why…

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Insights

Placebell©™ Predicts Placebo Response in Initial Study in Parkinson’s Disease

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, as it affects 1-2 per 1000 of the population at any time(1). Although it is primarily…

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Education

Placebo Effect vs. Placebo Response: Is There A Difference?

Placebo effect and placebo response are often used interchangeably – despite being two different phenomena. In this blog, we highlight the differences—and why it matters.   Placebos are an important…

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Education

Mitigating the Placebo Response in Phase II & III Clinical Trials

Phase II and III trial failure due to unexpectedly large placebo response rates is still all too common. In this blog, we explain what this means and…

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