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Embracing Human Complexity in Clinical Research
As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…
A New Era of Cognivia
Innovation, evolution and agility have always been core elements of drug and device development. How else, but through creative, out-of-the-box thinking and a willingness to innovate have…
Innovation with Integrity
It has taken a decade of scientific integrity and rigor – and a very particular mindset – for Cognivia to develop its current suite of innovative solutions….
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm
Abstract: Motor cortex repetitive transcranial magnetic stimulation (M1-rTMS) induces analgesic effects in neuropathic pain, but not all patients…
Embracing Human Complexity in Clinical Research
As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…
Capturing Patients Diversity as the Next Challenge in Drug Development? Insights from IASP 2024
Earlier this month, the IASP (International Association for the Study of Pain) meeting marked a significant moment in honoring the vision of Professor John Bonica founder of…
Covariate Adjustment in Randomized Clinical Trials Based on Latest FDA Guidance: Application to Composite Covariates
In May 2023, the US Food and Drug Administration (FDA) released its final guidance titled “Adjusting for Covariates in Randomized Clinical Trials (RCT) for Drugs and Biological Products”. It is difficult to overstate the importance of this guidance as baseline covariate adjustment is an integral part of any statistical analysis of RCTs. Covariate…
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