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Insights

The Placebo response in drug development Part 5: Pain

Placebo-controlled clinical trials are the gold standard in drug development, in part to ensure that the efficacy of a new therapy exceeds the placebo response in the…

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Publication

Leveraging historical data to optimize the number of covariates and their explained variance in the analysis of randomized clinical trials

The amount of data collected from patients involved in clinical trials is continuously growing. All baseline patient characteristics…

Type: Scientific Publication
Authors: Samuel Branders, Alvaro Pereira, Guillaume Bernard, Marie Ernst, Jamie Danenberg, Adelin Albert
Conference: Statistical Methods in Medical Research Journal
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Insights

Should strong placebo responders be excluded from clinical trials?

Using Predictive Modeling to understand the impact on assay sensitivity The placebo response is a heavily studied and historically challenging phenomenon for drug developers. Strong placebo effect…

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Publication

Impact of excluding highly variable pain subjects on the treatment estimation

The baseline pain variability (BPV) has often been presented as positively correlating with the placebo response (PR) and…

Type: Scientific Poster
Authors: Arthur Ooghe, Samuel Branders, Alvaro Pereira
Conference: CNS Summit
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Publication

Leveraging historical data for covariate adjustment in the analysis of randomized clinical trials

Scientific Poster presented on October 2021 at the Annual Meeting of the Royal Statistical Society of Belgium. The amount…

Type: Scientific Poster
Authors: Samuel Branders, Alvaro Pereira, Guillaume Bernard,Marie Ernst, Adelin Albert
Conference: Royal Statistical Society of Belgium
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Education

Top 3 Risks of Unchecked Placebo Response in Clinical Trials

Placebo response is one of the biggest threats to clinical data analysis– especially when left unchecked. In this blog, we review the top three risks trial scientists must address (and how to address them). 

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Education

How to Use ePRO to Understand the Impact of Decentralized Clinical Trials on Patients

In this article, we will first discuss the rise of DCTs, empowered by technology like ePRO in clinical trials. Then, we will review how related technology can…

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