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Introducing Cognivia Signal: Early-Warning Behavioral Risk Intelligence for Clinical Trials
Cognivia launches the world’s first early-warning behavioral risk intelligence dashboard—Cognivia Signal—empowering clinical teams to see what’s coming before it happens. Mont-Saint-Guibert, Belgium – October 9, 2025 – Cognivia,…
The Behavioral Layer: An Overlooked Determinant of Clinical Success
Clinical research continues to evolve at an impressive pace. Digital technologies streamline data capture, biomarkers deepen biological insight, and innovative trial designs broaden access for diverse populations. These advances have unquestionably accelerated development and expanded participant reach. Still, across all this progress, one dimension consistently shapes…
Placebo response modelled by psychological characteristics in a remote osteoarthritis trial
Background Accurately characterizing placebo response is essential for improving sensitivity in osteoarthritis (OA) trials. This analysis investigates how…
Why Patient Retention Still Fails in Clinical Trials — And How Predictive Signals Can Help Ops Teams Anticipate Drop‑Out Earlier ?
Patient retention or patient engagement have become a main operational challenge in today’s clinical trials. Despite major investments in decentralized models, engagement tools, and site‑facing technology, patient drop‑out still catches clinical operations teams by surprise. And when it does, the impact on timelines, data quality, and…
Analyzing Neuropathic Pain Subjects in Acute Low Back Pain Using an NPSI-Based Stratification Algorithm and PainDETECT Measurement
Background & Aims RCTs in neuropathic pain (NeP) are challenged by the high inter-individual variability in treatment response,…
ARE SITE DIFFERENCES DRIVING OUTCOMES? THE CENTRAL ROLE OF EXPECTATIONS IN OA RCTS.
Purpose Disparities among sites are frequently observed in the results of Randomized Controlled Trials (RCTs). As a result, adjusting…
From Chronic to Acute Pain: Evaluating the baseline prognostic covariates in Severe Acute Lower Back Pain
The FDA’s 2023 guidance on baseline covariate adjustment highlights the importance of incorporating prognostic covariates into randomized clinical…
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