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Insights

The placebo problem in pain: does baseline pain variability predict placebo response?

Recent reports have demonstrated a positive correlation between baseline pain variability and improvement in clinical trial patients receiving placebo, suggesting that patients with more highly variable reporting…

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Insights

Should strong placebo responders be excluded from clinical trials?

Using Predictive Modeling to understand the impact on assay sensitivity The placebo response is a heavily studied and historically challenging phenomenon for drug developers. Strong placebo effect…

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Publication

Impact of excluding highly variable pain subjects on the treatment estimation

The baseline pain variability (BPV) has often been presented as positively correlating with the placebo response (PR) and…

Type: Scientific Poster
Authors: Arthur Ooghe, Samuel Branders, Alvaro Pereira
Conference: CNS Summit
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Publication

Leveraging historical data for covariate adjustment in the analysis of randomized clinical trials

Scientific Poster presented on October 2021 at the Annual Meeting of the Royal Statistical Society of Belgium. The amount…

Type: Scientific Poster
Authors: Samuel Branders, Alvaro Pereira, Guillaume Bernard,Marie Ernst, Adelin Albert
Conference: Royal Statistical Society of Belgium
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Education

Top 3 Risks of Unchecked Placebo Response in Clinical Trials

Placebo response is one of the biggest threats to clinical data analysis– especially when left unchecked. In this blog, we review the top three risks trial scientists must address (and how to address them). 

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Education

How to Use ePRO to Understand the Impact of Decentralized Clinical Trials on Patients

In this article, we will first discuss the rise of DCTs, empowered by technology like ePRO in clinical trials. Then, we will review how related technology can…

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Publication

Should placebo responders be excluded from RCTs?

Scientific Poster presented on September 2021 at the International Society for CNS Clinical Trial and Methodology Conference The…

Type: Scientific Poster
Authors: Branders S., Pereira A., Demolle D.
Conference: ISCTM Autumn Conference
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