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Embracing Human Complexity in Clinical Research
As clinical trials become more diverse, patient heterogeneity, placebo responses, and inter-site variability become more pronounced, contributing to high rates of failed trials and extended development timelines…
The Placebo response in drug development Part 6: Allergy & immunology
The placebo response is widely known to compromise evaluation of pain endpoints and has been suggested to contribute to as much as ~2/3 of the measured treatment…
Using Artificial Intelligence-based Methods to Address the Placebo Response in Clinical Trials
Cognivia team members contribute critical elements to a recent paper published in Innovations in Clinical Neuroscience. Cognivia co-authored a…
Accounting for the high reduction of power due to floor effect in design of randomised controlled trials
Purpose Outcomes in Randomized Controlled Trials (RCT) are often computed as changes from baseline of finite scales (e.g.,…
The Placebo response in drug development Part 5: Pain
Placebo-controlled clinical trials are the gold standard in drug development, in part to ensure that the efficacy of a new therapy exceeds the placebo response in the…
Clinical Trial Technology: Why IT Infrastructure & Security Matters
From internal communication and management systems to tools sponsors deploy to improve operations and results, technology is everywhere in the clinical trial landscape. However, these technologies are…
Clinical Trial Technology & Project Management:
4 Aspects of Cognivia’s Approach
Many sponsors err on the side of reluctance when incorporating new technology in clinical trials. This is because some technologies have the potential to overly burden not…
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